Prof. Xiaomei Lyu | Genetic Engineering and Biotechnology | Best Researcher Award
Professor | Jiangnan University | China
Prof. Xiaomei Lyu is a leading researcher in synthetic biology-driven food science, microbial engineering, and biotechnology. Her work focuses on designing programmable microbial systems, metabolic pathway engineering, and CRISPR-based genetic regulation for applications in food functionality, metabolic health, and biomanufacturing. Her research contributions span high-impact areas such as microbial biosensing, host–microbe interaction engineering, and sustainable biosynthesis of value-added compounds. Prof. Xiaomei Lyu has contributed significantly to the development of engineered microbial genetic circuits targeting biomedical and functional-food applications. Her notable advancements include CRISPR-regulated biosensing systems and controllable nanocarriers enabling active delivery of gene-editing components (Small, 2021). She has also pioneered strategies for modularizing and optimizing metabolic pathways in microbial chassis to enhance production efficiency of nutraceutical compounds, as demonstrated in her work on delta-tocotrienol biosynthesis (Journal of Agricultural and Food Chemistry, 2023). Her research on Rhizobium-derived beta-glucan has opened new avenues in microbiota-modulated metabolic regulation. These works revealed mechanisms by which microbial polysaccharides influence triglyceride metabolism, intestinal fat absorption, and gut–host crosstalk, producing valuable implications for obesity and metabolic disorder interventions (Food & Function, 2022; 2024). Additionally, Prof. Xiaomei Lyu has made recognized contributions to enzymatic and chemo-catalytic processes relevant to food biotechnology, including lactulose production and salidroside biosynthesis, helping advance industrial and functional food innovation. Her publication record includes influential papers in Nature Communications, Small, Food & Function, Biotechnology Advances, Phytochemical Reviews, and Journal of Agricultural and Food Chemistry, supported by strong citation performance (Scopus: 1,515 citations, 59 documents, h-index 22). Her scholarly impact extends to R&D in microbial engineering, biochemical pathways, food-derived therapeutics, and microbiome-based metabolic interventions. Prof. Xiaomei Lyu’s research achievements establish her as a prominent contributor to next-generation microbial biotechnology, functional food science, and precision metabolic modulation.
Featured Publications
1. Gu, B., Zhang, W.-D., Feng, J.-D., Zhao, W., Gu, Z.-G., & Lyu, X. (2025). Upcycling CO₂ into single cell protein via an integrated electrocatalytic–biosynthetic system. ACS Sustainable Chemistry & Engineering. https://doi.org/10.1021/acssuschemeng.5c06506
2. Wang, L., Zeng, Q., Gu, J., Wang, M., Yang, R., & Lyu, X. (2025). High conversion of value-added lactulose from lactose-rich dairy waste by in vivo cascade cell factory. Journal of Agricultural and Food Chemistry. https://doi.org/10.1021/acs.jafc.5c03933
3. Zeng, Q., & Lyu, X. (2025). Identification of a novel cellobiose 2-epimerase from Acidobacteriota bacterium and its application for in-situ milk catalysis. Frontiers in Microbiology. https://doi.org/10.3389/fmicb.2025.1575725
4. Liu, H., Zeng, Q., Zhu, C., Xu, C., Yang, R., & Lyu, X. (2025). High-throughput screening and directed evolution of β-1,3-N-acetylglucosaminyltransferase for enhanced LNnT production in engineered Saccharomyces cerevisiae. Journal of Agricultural and Food Chemistry. https://doi.org/10.1021/acs.jafc.5c01311
5. Liu, H., Liu, Y., Hu, H., Zhang, S., Lyu, X., & Yang, R. (2024). De novo production of LNnT by metabolic engineering of Saccharomyces cerevisiae as cell factory. Food Science and Human Wellness. https://doi.org/10.26599/fshw.2024.9250342