Dr. Kalyan Kumar Sethi | Human Carbonic Anhydrase | Best Researcher Award

Asst. Professor at National Institutes of Pharmaceutical Education and Research, India.

Dr. Kalyan Kumar Sethi is an Assistant Professor of Medicinal Chemistry at the National Institute of Pharmaceutical Education and Research (NIPER), Guwahati, and the Founder Director of Dr. Sethi’s Laboratories Pvt. Ltd. His research expertise spans synthetic medicinal chemistry, natural product-based drug discovery, API synthesis, and computer-aided drug design. With over 12 years of academic and industrial experience, Dr. Sethi has contributed significantly to therapeutic development for cancer, microbial infections, and neurological disorders. He holds multiple Indian patents, has received prestigious grants such as the DST-SERB SRG and BIRAC-BIG, and serves as a reviewer and editorial board member for several international journals.

Publication Profile

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Educational Details

• Ph.D. (Pharmaceutical Sciences) – Birla Institute of Technology, Ranchi, India.

• M. Pharmacy (Pharmaceutical Chemistry) – Birla Institute of Technology, Ranchi, India.

• B. Pharmacy – Roland Institute of Pharmaceutical Sciences, Berhampur, India.

• 12th / 10th – Jawahar Navodaya Vidyalaya, Balasore, India.

Professional Experience

Total Academic & Industrial Experience: 12 years 10 months

• Founder Director, Dr. Sethi’s Laboratories Pvt. Ltd., Guwahati (Jun 2023 – Present)

• Assistant Professor, NIPER-Guwahati (Aug 2020 – Present)

• Senior Research Scientist, Trivedi Science and Research Lab (Feb 2016 – Aug 2020)

• Scientist cum Plant Manager, Biotechayur Pvt. Ltd., Balasore (Dec 2014 – Jan 2016)

• Institute Research Fellow, BIT Mesra (Oct 2011 – Nov 2014)

• Assistant Professor, GITAM Institute of Pharmacy (Jul 2009 – Sep 2011)

Supervision

• Ph.D. Students – 5

• M.S. (Pharm) Students – 13

• B. Pharm Students – 2

Patents

1. Granted: Process for preparation of Octopamine sulfate (202231000058)

2. Active hCAIs benzenesulfonamide compounds (202131017895) – Specification Filed

3. Lutein extraction from marigold flowers (202231062144) – Specification Filed

4. Pure curcumin derivatives from Lakadong turmeric (202231066460) – Specification Filed

5. Sulfonamides and methods thereof (202431098337) – Specification Filed

6. Tetrachloro isoindolinyl benzenesulfonamide derivatives (568/KOL/2013) – Published

Honors and Awards

• Bharat Shiksha Gaurav Puraskar & Certificate of Education Excellence (KTK Foundation, 2022)

• AD Scientific Index (2022), NIPER-Guwahati Ranking

• Rajiv Gandhi National Fellowship, UGC, 2014

• Institution Fellowship, BIT Mesra, 2011–2014

• AICTE Fellowship, 2007–2009

Invited Talks & Workshops

• Speaker, Flow Chemistry and Natural Products Symposium (NIPER Kolkata, 2023)

• Speaker, National Workshop on Herbal Enrichment Techniques (NIPER Guwahati, 2024)

• Speaker, TIFAC–NIPER Workshop on TRL 6+ Tech, 2022

• AICTE-STTP on QbD in Drug Development, 2021

• Organizer, multiple international hands-on workshops on molecular modeling (2021–2022)

Professional Memberships & Recognition

• GATE Qualified (2006, 2007, 2008)

• Member, Indian Pharmacy Graduates Association (IPGA)

• Editorial Board Member: EC Pharmacology and Toxicology

• Reviewer: Bioorganic & Medicinal Chemistry, Arabian Journal of Chemistry, OBC (RSC), and others

Technical Skills

• Instruments: LC-MS, GC-MS, NMR, PXRD, UV-Vis, FT-IR, DSC, TGA, CHNSO, Microwave Synthesizer

• Techniques: Human CA inhibition assays, antimicrobial testing, bioassays, and preclinical animal studies

• Scale-Up: Spray Dryer, Tray Dryer, Pulverizer, etc.

• CADD Software: SYBYL, Maestro, AutoDock, ChemSketch, UCSF Chimera

Research Interest

• Synthetic Medicinal Chemistry & Drug Discovery

• API and KSM Synthesis

• Natural Product Chemistry (Extraction, Isolation, Purification, Characterization)

• Therapeutic Targets:

  • Microorganisms (HCV, Bacteria)

  • Cancer (hCA, HuR, HDAC)

  • Neurological Disorders (Epilepsy, Alzheimer’s disease)

• Analytical & Bioanalytical Studies

• Computer-Aided Drug Design (CADD): SYBYL, Maestro, AutoDock, UCSF Chimera

• Technology Transfer and Herbal Manufacturing at Industrial Scale

Author Metrics

• Total Citations: 734

• h-index: 14

• i10-index: 19

These metrics indicate that Dr. Sethi has published at least:

• 14 papers with ≥14 citations each (h-index),

• 19 papers with ≥10 citations each (i10-index),

• and a total of 734 citations across all his scholarly work (as of May 2025).

Top Noted Publication

• A comprehensive physicochemical, thermal, and spectroscopic characterization of zinc (II) chloride using X-ray diffraction, particle size distribution, differential scanning calorimetry, and thermogravimetric analysis.

  • Authors: MK Trivedi, KK Sethi, P Panda, S Jana

  • Journal: International Journal of Pharmaceutical Investigation

  • Volume: 7

  • Issue: 1

  • Pages: 33-40

  • Year: 2017

  • Citations: 97

• Metabolite Profiling in Withania somnifera Roots Hydroalcoholic Extract Using LC/MS, GC/MS and NMR Spectroscopy.

  • Authors: MK Trivedi, P Panda, KK Sethi, S Jana

  • Journal: Chemistry & Biodiversity

  • Volume: 14

  • Issue: 3

  • Article ID: e1600280

  • Year: 2017

  • Citations: 86

• Physicochemical, Thermal and Spectroscopic Characterization of Sodium Selenate Using XRD, PSD, DSC, TGA/DTG, UV-vis, and FT-IR.

  • Authors: MK Trivedi, KK Sethi, P Panda, S Jana

  • Journal: Marmara Pharmaceutical Journal

  • Volume: 21

  • Issue: 2

  • Pages: 311-318

  • Year: 2017

  • Citations: 74

• Gas chromatography-mass spectrometry based isotopic abundance ratio analysis of biofield energy treated methyl-2-napthylether (Nerolin).

  • Authors: MK Trivedi, A Branton, D Trivedi, G Nayak, KK Sethi, S Jana

  • Journal: American Journal of Physical Chemistry

  • Volume: 5

  • Issue: 4

  • Pages: 80-86

  • Year: 2016

  • Citations: 65

• Solid and liquid state characterization of tetrahydrocurcumin using XRPD, FT-IR, DSC, TGA, LC-MS, GC-MS, and NMR and its biological activities.

  • Authors: MK Trivedi, P Panda, KK Sethi, M Gangwar, SC Mondal, S Jana

  • Journal: Journal of Pharmaceutical Analysis

  • Volume: 10

  • Issue: 4

  • Pages: 334-345

  • Year: 2020

  • Citations: 51

Conclusion

Dr. Kalyan Kumar Sethi demonstrates all the qualities of a strong candidate for the Best Researcher Award. His solid academic foundation, extensive research experience, contributions to drug discovery, leadership in teaching, and commitment to innovation set him apart as a leader in his field. By expanding the international reach of his collaborations and further diversifying his research, he has the potential to significantly amplify his impact on the global scientific community. Thus, Dr. Sethi is a deserving candidate for the Best Researcher Award, and his future contributions are expected to continue to shape and advance the field of medicinal chemistry and drug discovery.