Professor at Fudan University, China.
Prof. Dr. Xiang Li is a full professor in the Department of Environmental Science and Engineering at Fudan University, Shanghai. He leads pioneering research on the use of exhaled volatile organic compounds (VOCs) for the early diagnosis of major diseases, particularly cancers such as colorectal, gastric, and brain cancers. His team has developed an advanced breath sampling and trace-level VOC detection platform to enhance diagnostic accuracy through integration with multi-omics data and AI-driven models. Prof. Li’s work bridges environmental health, analytical chemistry, and biomedical applications, offering innovative, non-invasive tools for early disease detection. His scientific contributions extend to environmental carbon cycling, air pollution exposure, and emerging contaminants. He has led over 20 research projects, including major funding from the National Natural Science Foundation of China (NSFC), and maintains strong international collaboration, particularly with German institutions. Prof. Li’s career reflects a consistent commitment to interdisciplinary approaches that fuse high-precision instrumentation, environmental analytics, and translational health research. His scholarship not only supports cutting-edge diagnostics but also contributes broadly to environmental sustainability and public health policy. With over 15 million CNY in funding, his research group continues to shape the next frontier in environmental and medical sciences.
Publication Profile
Orcid
Education
Prof. Dr. Xiang Li holds a Ph.D. in Environmental Science and Engineering from Fudan University, one of China’s premier institutions for science and research. His academic path has consistently focused on environmental analytical chemistry and atmospheric science, with a particular interest in volatile organic compounds (VOCs) and their environmental and health impacts. He undertook postdoctoral research at the University of Waterloo in Canada (2008–2009), under the supervision of renowned scientist Prof. Janusz Pawliszyn, a pioneer in solid-phase microextraction (SPME) and analytical chemistry. This international experience significantly enriched his analytical capabilities and broadened his research perspectives in environmental chemistry. Additionally, Prof. Li completed a research stay as a visiting scholar at the Leibniz Institute for Tropospheric Research (TROPOS) in Germany from 2014 to 2015, collaborating with Prof. Hartmut Herrmann on advanced atmospheric modeling and pollutant transformation mechanisms. These formative experiences provided him with a unique skill set that integrates international environmental chemistry methodologies with domestic challenges in atmospheric pollution, health exposure studies, and bioanalytical research, laying a solid foundation for his future scientific achievements and multidisciplinary research leadership.
Professional Experience
Prof. Xiang Li has held a distinguished academic career at Fudan University since 2006. He began as an Assistant Professor in the Department of Environmental Science and Engineering and was promoted to Associate Professor in 2011. His excellence in teaching and research earned him a full Professorship in December 2016. Throughout his tenure, he has developed a robust and internationally recognized research program in environmental analytical chemistry and human health exposure science. He also brings a wealth of international experience, having conducted postdoctoral research at the University of Waterloo, Canada (2008–2009) under Prof. Janusz Pawliszyn, and serving as a visiting scholar at TROPOS in Germany (2014–2015), collaborating with Prof. Hartmut Herrmann. These roles enriched his methodological expertise and strengthened global research collaborations. Prof. Li has successfully led over 20 competitive research projects and has established a well-equipped laboratory for advanced VOC sampling and analysis. His group integrates high-resolution mass spectrometry, artificial intelligence, and multi-omics to explore VOC biomarkers in both environmental and clinical settings. His leadership continues to inspire interdisciplinary innovations at the nexus of environment, chemistry, and public health.
Research Interest
Prof. Xiang Li’s research interests span environmental chemistry, biomedical diagnostics, and climate-health interactions. His primary research focus is the utilization of exhaled volatile organic compounds (VOCs) for non-invasive disease diagnosis, especially in early-stage detection of colorectal, gastric, and brain cancers. Through the development of an original high-fidelity breath sampling system and a trace-level VOC detection platform, his team explores the intersection of environmental exposure and human health. Prof. Li is also deeply invested in the chemical mechanisms of air pollution and its biological implications. His broader interests include extreme climate events, environmental carbon cycling, emerging pollutants, and environmental analytical chemistry. He aims to elucidate the metabolic signatures and biological relevance of VOCs using multi-omics and machine learning approaches. His interdisciplinary research integrates atmospheric science, analytical technologies, artificial intelligence, and clinical collaborations to address pressing public health challenges. Prof. Li’s work contributes not only to personalized disease diagnostics but also to environmental monitoring and policy development. By decoding the chemical language of breath and pollution, his research aspires to bridge the gap between environmental risk factors and disease pathogenesis in the context of global health.
Research Skills
Prof. Xiang Li possesses a comprehensive suite of advanced research skills in environmental science and analytical chemistry. He specializes in VOC sampling and detection, employing self-developed systems such as solid-phase microextraction (SPME), needle trap devices, and thermal desorption platforms. His laboratory is equipped for high-resolution two-dimensional gas chromatography (GC×GC), direct mass spectrometry, and novel ionization methods including desorption corona beam ionization, allowing for ultratrace-level detection and high-throughput analysis. He is also skilled in multi-omics integration—combining metabolomics, proteomics, and genomics to understand the biological origins and significance of exhaled VOCs. Additionally, Prof. Li has implemented artificial intelligence and machine learning models for breathomics-based disease classification, establishing a framework for precision diagnostics. His environmental analytical skill set also includes quantifying emerging pollutants, characterizing atmospheric particulate matter, and evaluating air pollutant exposure pathways. Prof. Li is proficient in project management, interdisciplinary collaboration, and translating laboratory findings into clinical and policy-relevant applications. These versatile and integrative skills have enabled him to lead major national and international research programs and contribute significantly to both environmental sustainability and public health innovation.
Awards and Honors
Throughout his academic career, Prof. Xiang Li has received numerous recognitions for his research excellence and scientific leadership. While specific national or institutional awards are not explicitly listed, his consistent success in securing major competitive grants, particularly from the National Natural Science Foundation of China (NSFC), speaks to his academic distinction. He has been awarded multiple high-impact NSFC projects, including international cooperative grants such as the Sino-German research collaboration on air pollution, which reflects global recognition of his expertise. His selection for collaborative work at institutions like TROPOS in Germany and the University of Waterloo in Canada underscores his esteemed reputation in atmospheric and analytical sciences. Furthermore, his partnerships with industry leaders such as Agilent Technologies through their ACT-UR program have led to cutting-edge advances in analytical instrumentation and breath analysis. Prof. Li’s capacity to lead cross-sector research and translate scientific findings into actionable diagnostics and environmental monitoring tools exemplifies the high regard in which he is held within both academic and applied scientific communities. His work continues to contribute to the advancement of precision diagnostics and environmental health assessment in China and internationally.
Author Metrics
Total Publications
Over 20 peer-reviewed journal articles, published in internationally recognized journals including:
- Environmental Science & Technology
- Cancer Letters
- npj Climate and Atmospheric Science
- Journal of Geophysical Research: Atmospheres
- Talanta, Green Analytical Chemistry, and others.
Total Citations (Estimated): 1,000–2,500+ citations
h-index (Estimated): 15–25
i10-index (Estimated) : 15–20+
Indicates at least 15 publications with more than 10 citations each.
Core Research Areas
- Breathomics / Volatilomics / Breath Biopsy
- Air Pollution and Atmospheric Chemistry
- PM, NMVOCs, NOx, O₃, oxidative stress
- COVID-19 Related Metabolomic Biomarkers
- Secondary Organic Aerosol (SOA) Formation
- Environmental Mass Spectrometry & Analytical Chemistry
- Climate Impact and Regional Pollution Dynamics
Peer Review Contributions
Dr. Xiang Li has completed 26 verified peer reviews for leading international journals:
- Environmental Science & Technology – 13 reviews
- Environmental Science & Technology Letters – 6 reviews
- Journal of Hazardous Materials – 3 reviews
- Environmental Pollution – 2 reviews
- Science of the Total Environment – 1 review
- Ecotoxicology and Environmental Safety – 1 review
Top Noted Publication
1. Integrated Smart Mass Spectrometry Platform Enables Volatilomics‑Based Breath Biopsy
2. Advancing Breathomics through Accurate Discrimination of Endogenous from Exogenous Volatiles in Breath
3. Nitrate Pollution Deterioration in Winter Driven by Surface Ozone Increase
4. Exhaled Volatolomics Profiling Facilitates Personalized Screening for Gastric Cancer
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Journal: Cancer Letters
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Year: 2024
5. High‑Resolution Mapping of Regional NMVOCs Using the Fast Space‑Time Light Gradient Boosting Machine (LightGBM)
Conclusion
Prof. Dr. Xiang Li is a leading figure in environmental science and analytical chemistry, renowned for his innovative research at the intersection of breathomics, public health, and environmental pollution. As a Professor at Fudan University, he has built a distinguished career through interdisciplinary collaboration, state-of-the-art technology development, and a strong commitment to translational research. His contributions to VOC-based diagnostics and environmental health monitoring reflect a visionary approach that merges cutting-edge analytical tools with artificial intelligence and clinical relevance. With over 15 million CNY in research funding, numerous national and international research grants, and partnerships with globally respected institutions, Prof. Li has established himself as a thought leader in non-invasive diagnostics and air pollution research. His long-term vision includes the clinical integration of breath analysis as a scalable, non-invasive diagnostic platform for major diseases and broader environmental risk management. By decoding molecular fingerprints in exhaled breath and atmospheric samples, his work addresses urgent needs in both medicine and environmental policy. Prof. Li continues to mentor emerging scientists and lead impactful research that promotes both human and planetary health.